γ-Aminobutyric acidA neurotransmission and cerebral ischemia
نویسندگان
چکیده
منابع مشابه
g-Aminobutyric acidA neurotransmission and cerebral ischemia
In this review, we present evidence for the role of g-aminobutyric acid (GABA) neurotransmission in cerebral ischemia-induced neuronal death. While glutamate neurotransmission has received widespread attention in this area of study, relatively few investigators have focused on the ischemia-induced alterations in inhibitory neurotransmission. We present a review of the effects of cerebral ischem...
متن کاملRegulation of Uterine γ-Aminobutyric AcidA Receptor Subunit Expression throughout Pregnancy.
Uterine contractions at parturition depend upon a variety of factors, including gamma-aminobutyric acid (GABA)-ergic stimulation. A new subunit of the GABA(A) receptor, pi, has recently been identified as being particularly abundant in the rat uterus. Reduced derivatives of progesterone, such as the 3alpha,5alpha-reduced derivative termed allopregnanolone, modulate GABA(A) receptor activity and...
متن کاملEnhancement of g-Aminobutyric AcidA Receptor Activity by a-Chloralose
a-Chloralose is widely used as an anesthetic in the laboratory due to its minimal effects on autonomic and cardiovascular systems, yet little is known about its mechanism of action. We examined the effects of a-chloralose on g-aminobutyric acid type A (GABAA) receptor activity because recent studies have shown that several classes of general anesthetics modulate the function of this receptor. G...
متن کاملMutational analysis of molecular requirements for the actions of general anaesthetics at the γ-aminobutyric acidA receptor subtype, α1β2γ2
BACKGROUND Amino acids in the beta subunit contribute to the action of general anaesthetics on GABA(A) receptors. We have now characterized the phenotypic effect of two beta subunit mutations in the most abundant GABA(A) receptor subtype, alpha1beta2gamma2. RESULTS The beta2(N265M) mutation in M2 decreased the modulatory actions of propofol, etomidate and enflurane, but not of alphaxalone, wh...
متن کاملCloning of genomic and cDNA sequences encoding an invertebrate gamma-aminobutyric acidA receptor subunit.
11. Shivers, B. D., Killisch, I., Sprengel, R., Sontheimer, H., Kohler, M., Schofield, P. R. & Seeburg, P. H. (1989) Neuron 3,327-337 Sieghart, W. ( I 989) Trends Pharmacol. Sci. 10,407-41 1 Wisden, W., Morris, B. J., Darlison, M. G., Hunt, S. P. & Barnard, E. A. (1 988) Neuron I , 937-947 Wisden, W., Morris, B. J., Darlison, M. G., Hunt, S. P. & Barnard, E. A. ( 1989) Mol. Brain Res. 5,305-3 1...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2001
ISSN: 0022-3042,1471-4159
DOI: 10.1046/j.1471-4159.2001.00274.x